000 02234nam a22003378i 4500
001 CR9781139049627
003 UkCbUP
005 20170526205634.0
006 m|||||o||d||||||||
007 cr||||||||||||
008 110307s2011||||enk o ||1 0|eng|d
020 _a9781139049627 (ebook)
020 _z9780521769501 (hardback)
040 _aUkCbUP
_beng
_erda
_cUkCbUP
050 0 0 _aQP301
_b.V53 2012
082 0 0 _a612.7
_223
100 1 _aViceconti, Marco,
_eauthor.
245 1 0 _aMultiscale Modeling of the Skeletal System /
_cMarco Viceconti.
264 1 _aCambridge :
_bCambridge University Press,
_c2011.
300 _a1 online resource (222 pages) :
_bdigital, PDF file(s).
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
500 _aTitle from publisher's bibliographic system (viewed on 28 Feb 2017).
520 _aIntegrative approaches to biomedical research promise to advance our understanding of the human body and physiopathology of diseases. In this book, the author focuses on the skeletal system, demonstrating how multiscale modeling can determine the relationship between bone mechanics and disease. Introductory chapters explain the concept of integrative research, what a model is, predictive modeling, and the computational methods used throughout the book. Starting with whole body anatomy, physiology and modeling, subsequent chapters scale down from bone and tissue levels to the cellular level, where the modeling of mechanobiological processes is addressed. Finally, the principles are applied to address truly complex, multiscale interactions. Special attention is given to real-world clinical applications: one in pediatric skeletal oncology and one on the prediction of fracture risks in osteoporotic patients. This book has wide interdisciplinary appeal and is a valuable resource for researchers in mechanical and biomedical engineering, quantitative physiology and computational biology.
650 0 _aMultiscale modeling
650 0 _aModels, Biological
650 0 _aMusculoskeletal Physiological Phenomena
776 0 8 _iPrint version:
_z9780521769501
856 4 0 _uhttps://doi.org/10.1017/CBO9781139049627
999 _c123913
_d123913